Bono's daughter, Eve Hewson, told him to 'stick to your day job' when he asked if he should appear alongside Beyoncé, while she herself pursues a career in acting.
Hewson has just landed herself a role in a new US Series The Knick, which follows the staff of a failing Hospital in the 20th Century.
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The 23-year-old stars along side Clive Owen in the new Cinemax mini series set to premier in August.
Hewson plays Lucy, a nurse in the hospital, a role for which she had to practice an American accent, learn the basics of 20th Century medicine and overcome her fear of needles.